细胞死亡活化蛋白抗体 - 北京拜尔迪生物技术有限公司

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细胞死亡活化蛋白抗体

产品货号：

BN41952R
中文名称：

细胞死亡活化蛋白抗体
英文名称：

Rabbit anti-CIDEC Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41952R-50ul

50ul

¥1486.00

交叉反应：Human,Mouse,Rat(predicted:Pig) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41952R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat(predicted:Pig) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41952R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse,Rat(predicted:Pig) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称	CIDEC
中文名称	细胞死亡活化蛋白抗体
别名	Cell Death Activator; Cell death activator CIDE-3; Cell Death Inducing DFFA Like Effector C; Cell death inducing DFFA like effector protein C; Cell death-inducing DFFA-like effector protein C; CIDE 3; CIDE3; CIDE C; CIDEC_HUMAN; Fat specific protein 27; Fat-specific protein FSP27 homolog; FLJ20871; FSP27.
研究领域	肿瘤心血管细胞生物免疫学信号转导细胞凋亡表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Pig, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	27kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human CIDEC:101-200/238
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. Tissue specificity: Expressed mainly in small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver. Function: May act as a CEBPB coactivator in white adipose tissueto control the expression of a subset of CEBPB downstream targetgenes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (Bysimilarity). Binds to lipid droplets and regulates theirenlargement, thereby restricting lipolysis and favoring storage. Atfocal contact sites between lipid droplets, promotes directionalnet neutral lipid transfer from the smaller to larger lipiddroplets. The transfer direction may be driven by the internalpressure difference between the contacting lipid droplet pair. Whenoverexpressed in preadipocytes, induces apoptosis or increases cellsusceptibility to apoptosis induced by serum deprivation or TGFBtreatment. As mature adipocytes, that express high CIDEC levels,are quite resistant to apoptotic stimuli, the physiologicalsignificance of its role in apoptosis is unclear. Subunit: Interacts with CEBPB (By similarity). Interacts withCIDEA. Subcellular Location: Nucleus (By similarity). Endoplasmicreticulum (By similarity). Lipid droplet. Note=Diffuses quickly onlipid droplet surface, but becomes trapped and clustered at lipiddroplet contact sites, thereby enabling its rapid enrichment atlipid droplet contact sites. Tissue Specificity: Expressed mainly in adipose tissue, smallintestine, heart, colon and stomach and, at lower levels, in brain,kidney and liver. Post-translational modifications: Ubiquitinated and targeted to proteasomal degradation,resulting in a short half-life. Protein stability depends ontriaclyglycerol synthesis, fatty acid availability and lipiddroplet formation (By similarity). DISEASE: Note=In omental adipose tissue of obese patients matchedfor BMI, expression levels tend to correlate with insulinsensitivity. Expression is increased 2-3 fold in the group ofpatients with high insulin sensitivity, compared to theinsulin-resistant group. This observation is consistent with theidea that triglyceride storage in adipocytes plays an importantrole in sequestering triglycerides and fatty acids away from thecirculation and peripheral tissues, thus enhancing insulinsensitivity in liver and muscle. This effect is not significant insubcutaneous adipose tissue (PubMed:18509062). In subcutaneousadipose tissue of diabetic patients, tends to negatively correlatewith body mass index and total fat mass, independently of insulinsensitivity (PubMed:18334488). Similarity: Contains 1 CIDE-N domain. SWISS: Q96AQ7 Gene ID: 63924 Database links: Entrez Gene: 63924 Human Entrez Gene: 14311 Mouse Entrez Gene: 500292 Rat Omim: 612120 Human SwissProt: Q96AQ7 Human SwissProt: P56198 Mouse SwissProt: Q5XI33 Rat Unigene: 567562 Human Unigene: 635072 Human Unigene: 10026 Mouse Unigene: 33794 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.