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BN41888R-50ul
50ul
¥1486.00
交叉反应：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：WB,IHC-P,Flow-Cyt,ELISA
BN41888R-100ul
100ul
¥2360.00
交叉反应：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：WB,IHC-P,Flow-Cyt,ELISA
BN41888R-200ul
200ul
¥3490.00
交叉反应：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：WB,IHC-P,Flow-Cyt,ELISA
产品描述
| 英文名称 | Glucose 6 phosphatase alpha |
| 中文名称 | 葡萄糖6磷酸酶α/G6Pase-α抗体 |
| 别 名 | glucose-6-phosphatase, catalytic subunit; GSD1; AW107337; G-6-Pase; G6Pase; G6Pase-alpha; g6pc; G6PC_HUMAN; G6PT; Glucose-6-phosphatase alpha; Glucose-6-phosphatase; GSD1a; MGC163350; MGC93613; RP23-281C18.19. |
| 研究领域 | 肿瘤 免疫学 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Rabbit, Sheep, ) |
| 产品应用 | ELISA=1:5000-10000 Flow-Cyt=0.2ug/test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Glucose 6 phosphatase alpha:81-180/357 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011] Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. DISEASE: Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A) [MIM:232200]. A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Similarity: Belongs to the glucose-6-phosphatase family. SWISS: P35575 Gene ID: 2538 Database links: Entrez Gene: 2538 Human Entrez Gene: 14377 Mouse SwissProt: P35575 Human SwissProt: P35576 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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