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BN41800R-50ul
50ul
¥1486.00
交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB
BN41800R-100ul
100ul
¥2360.00
交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB
BN41800R-200ul
200ul
¥3490.00
交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB
产品描述
| 英文名称 | Periplakin |
| 中文名称 | 周斑蛋白抗体 |
| 别 名 | 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor; 195 kDa cornified envelope precursor protein; AW553870; KIAA0568; MGC134872; PEPL_HUMAN; Periplakin; ppl. |
| 研究领域 | 肿瘤 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, ) |
| 产品应用 | WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 205kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Periplakin:1-100/1756 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008] Function: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. Subcellular Location: Cell junction > desmosome. Cytoplasm > cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments. Tissue Specificity: Expressed in stratified squamous epithelia and in some other epithelia. Similarity: Belongs to the plakin or cytolinker family. Contains 2 plectin repeats. Contains 4 spectrin repeats. SWISS: O60437 Gene ID: 5493 Database links: Entrez Gene: 5493 Human Entrez Gene: 19041 Mouse Omim: 602871 Human SwissProt: O60437 Human SwissProt: Q9R269 Mouse Unigene: 192233 Human Unigene: 266875 Mouse Unigene: 25259 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
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