在线咨询
English
最近搜索：细胞培养 微生物学 分子生物 生物化学
最近搜索：细胞培养 微生物学 分子生物 生物化学
首页>>免疫学>>一抗>>血管内皮细胞粘附分子抗体
血管内皮细胞粘附分子抗体
  • 产品货号：
    BN41598R
  • 中文名称：
    血管内皮细胞粘附分子抗体
  • 英文名称：
    Rabbit anti-VCAM1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41598R-50ul

    50ul

    ¥1486.00

    交叉反应：Sheep,Rabbit,Mouse,Human(predicted:Pig,Rat) 推荐应用：WB,ELISA

  • BN41598R-100ul

    100ul

    ¥2360.00

    交叉反应：Sheep,Rabbit,Mouse,Human(predicted:Pig,Rat) 推荐应用：WB,ELISA

产品描述

英文名称VCAM1
中文名称血管内皮细胞粘附分子抗体
别    名CD 106; CD106; CD106 Antigen; DKFZp779G2333; INCAM 100; MGC99561; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; INCAM-100; V-CAM 1; VCAM1_HUMAN.  


研究领域肿瘤  心血管  细胞生物  细胞粘附分子  内皮细胞  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rabbit, Sheep,  (predicted: Rat, Pig, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human VCAM-1:651-739/739 <Cytoplasmic>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.

Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Subunit:
Binds to ECMV-D capsid proteins and acts as a receptor for this virus.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.

Similarity:
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P19320

Gene ID:
7412

Database links:

Entrez Gene: 7412 Human

Entrez Gene: 22329 Mouse

Entrez Gene: 25361 Rat

GenBank: NP_001069.1 Human

GenBank: NP_001186763.1 Human

Omim: 192225 Human

SwissProt: P19320 Human

SwissProt: P29533 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞粘附蛋白（Call Adhesion Protein）
CD106是一种膜相关蛋白，分布于血管内皮及其周围的淋巴细胞、单核细胞、嗜酸性粒细胞和中性粒细胞。Anti-VCAM-1主要用于各种组织中血管内皮的检测。
















image.png