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首页>>免疫学>>一抗>>高迁移率族蛋白B1抗体
高迁移率族蛋白B1抗体
  • 产品货号：
    BN41571R
  • 中文名称：
    高迁移率族蛋白B1抗体
  • 英文名称：
    Rabbit anti-HMGB1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41571R-50ul

    50ul

    ¥1486.00

    交叉反应：Rat,Mouse,Human(predicted:Cow) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41571R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat,Mouse,Human(predicted:Cow) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41571R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat,Mouse,Human(predicted:Cow) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

产品描述

英文名称HMGB1
中文名称高迁移率族蛋白B1抗体
别    名Amphoterin; High mobility group 1; High Mobility Group Box 1; High mobility group protein 1; High mobility group protein B1; HMG3; HMGB 1;HMGB-1; Hmgb1 protein; Nonhistone chromosomal protein HMG1; SBP 1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; HMGB1_HUMAN.  



研究领域肿瘤  细胞生物  免疫学  转录调节因子  结合蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,  (predicted: Cow, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HMGB1:75-170/215 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve dependent mechanism, inhibits HMGB1 release in experimental disease models

Function:
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.

Subunit:
Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2.

Subcellular Location:
Nucleus. Chromosome.

Similarity:
Belongs to the HMGB family.
Contains 2 HMG box DNA-binding domains.

SWISS:
P09429

Gene ID:
3146

Database links:

Entrez Gene: 282691 Cow

Entrez Gene: 3146 Human

Entrez Gene: 100862258 Mouse

Entrez Gene: 15289 Mouse

Entrez Gene: 25459 Rat

Omim: 163905 Human

SwissProt: P10103 Cow

SwissProt: P09429 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

近来的研究表明称之为高迁移率族蛋白B-1（HMG-B1）的核内结构蛋白在核外表达时是一种有效的早期炎症介质。
高迁移性Ｂ１组蛋白（ＨＭＧＢ１）： 是一种核结合蛋白，在ＤＮＡ重组、修复、复制和基因转录中起作用。ＨＭＧＢ１也是巨噬细胞分泌的一种介质。
此外，高迁移性Ｂ１组蛋白亦被受刺激的巨噬细胞或单核细胞主动分泌。在这一主动分泌过程中，HMGB1首先经乙酰化并由核内转移至溶酶体内，继而在ATP和溶血磷脂胆碱两种分泌信号指导下转移至细胞外。由坏死细胞被动释放的HMGB1和炎症细胞主动分泌的HMGB1存在分子上的差异。胞外的HMGB1可作为细胞因子参与信号传导，因为它既可识别Toll 样受体（TLR）家族的一些成员，又能与识别晚期糖基化终末产物受体（RAGE）相作用。
HMGB1能启动炎症反应，包括产生多种细胞因子、对某些干细胞产生趋化作用、诱导血管粘附分子、削弱肠上皮细胞的功能等。