F-box蛋白家族FBXO25抗体

产品货号：

BN41330R
中文名称：

F-box蛋白家族FBXO25抗体
英文名称：

Rabbit anti-FBXO25 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41330R-100ul

100ul

¥2360.00

交叉反应：Mouse,Rat(predicted:Human,Pig,Rabbit) 推荐应用：WB,ELISA
BN41330R-200ul

200ul

¥3490.00

交叉反应：Mouse,Rat(predicted:Human,Pig,Rabbit) 推荐应用：WB,ELISA

产品描述

英文名称	FBXO25
中文名称	F-box蛋白家族FBXO25抗体
别名	F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25; MGC20256; MGC51975; OTTHUMP00000115399;
研究领域	细胞生物免疫学信号转导转录调节因子表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, Rat, (predicted: Human, Pig, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	43kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human FBXO25:55-150/367
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	FBXO25 is a member of the F box protein family which is characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1 cullin F box), which function in phosphorylation dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD 40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein protein interaction modules or no recognizable motifs. FBXO25 belongs to the Fbxs class. There are three named isoforms produced by alternative splicing. FBXO25, also known as FBX25, is a 367 amino acid protein that contains one C-terminal F-box domain and belongs to the Fbx class of the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Expressed at high levels in brain, FBXO25 localizes predominantly to the nucleus and directly interacts with Skp1 p19 and CUL-1. Disruption of the gene encoding FBXO25 can lead to X-linked mental retardation. Function: Substrate-recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mayplay a role in accumulation of expanded polyglutamine (polyQ)protein huntingtin (HTT) (By similarity). Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complexconsisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly withSKP1 and CUL1. Interacts (via C-terminus) with beta-actin (viaN-terminus). Subcellular Location: Nuclear. Note=In the nucleus, associateswith a subnuclear dot-like structure. Colocalized with SKP1 Tissue Specificity: Expressed in all brain tissue observed. DISEASE: Note=A chromosomal aberration involving FBXO25 is a causeof X-linked mental retardation (XLMR). Translocationt(X;8)(p11.22;p23.3) with SHROOM4. Similarity: Contains 1 F-box domain. SWISS: Q8TCJ0 Gene ID: 26260 Database links: Entrez Gene: 26260 Human Entrez Gene: 66822 Mouse Entrez Gene: 364637 Rat Omim: 609098 Human SwissProt: Q1RMS8 Cow SwissProt: Q8TCJ0 Human SwissProt: Q9D2Y6 Mouse SwissProt: Q641X7 Rat Unigene: 438454 Human Unigene: 37950 Mouse Unigene: 3663 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.