组蛋白H4-K4甲基转移酶抗体

产品货号：

BN41197R
中文名称：

组蛋白H4-K4甲基转移酶抗体
英文名称：

Rabbit anti-H3-K4-HMTase SETD7 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41197R-100ul

100ul

¥2360.00

交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41197R-200ul

200ul

¥3490.00

交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	H3-K4-HMTase SETD7
中文名称	组蛋白H4-K4甲基转移酶抗体
别名	FLJ21193; H3 K4 HMTase; H3-K4-HMTase SETD7; H4 lysine 4 specific; Histone H3 K4 methyltransferase; Histone H3 lysine 4 specific methyltransferase; Histone H3-K4 methyltransferase SETD7; Histone H4 K4 methyltransferase; Histone lysine N methyltransferase; Histone lysine N methyltransferase H3 lysine 4 specific SET7; Histone-lysine N-methyltransferase SETD7; KIAA1717; KMT7; Lysine methyltransferase; Lysine N-methyltransferase 7; OTTHUMP00000164543; OTTHUMP00000220049; SET 7; SET 7/9; SET 9; SET D7; SET domain containing (lysine methyltransferase) 7; SET domain containing protein 7; SET domain containing protein 8; SET domain-containing protein 7; SET7; SET7/9; SET9; Setd7; SETD7_HUMAN.
研究领域	染色质和核信号表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	41kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Histone H4 K4 methyltransferase SETD7:271-366/366
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro. Function: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Subunit: Interacts with IPF1/PDX-1. Subcellular Location: Nucleus. Chromosome (Probable). Tissue Specificity: Widely expressed. Expressed in pancreatic islets. Similarity: Belongs to the histone-lysine methyltransferase family. SET7 subfamily. Contains 3 MORN repeats. Contains 1 SET domain. SWISS: Q8WTS6 Gene ID: 80854 Database links: Entrez Gene: 80854 Human Entrez Gene: 73251 Mouse Omim: 606594 Human SwissProt: Q8WTS6 Human SwissProt: Q8VHL1 Mouse Unigene: 480792 Human Unigene: 192111 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.