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分子生物钟调控蛋白NOC抗体
  • 产品货号:
    BN40304R
  • 中文名称:
    分子生物钟调控蛋白NOC抗体
  • 英文名称:
    Rabbit anti-Nocturnin Polyclonal antibody
  • 品牌:
    Biorigin
  • 货号

    产品规格

    售价

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  • BN40304R-100ul

    100ul

    ¥1900.00

    交叉反应(总):Human,Mouse,Rat,Chicken,Pig,Horse,Sheep,;推荐应用:IHC-P,

  • BN40304R-200ul

    200ul

    ¥2700.00

    交叉反应(总):Human,Mouse,Rat,Chicken,Pig,Horse,Sheep,;推荐应用:IHC-P,

产品描述

英文名称Nocturnin
中文名称分子生物钟调控蛋白NOC抗体
别    名CCR4 carbon catabolite repression 4 like (S. cerevisiae); CCR4 protein homolog; CCRN4L; NOC; NOCT_HUMAN.  
研究领域细胞生物  神经生物学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Chicken, Pig, Horse, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Nocturnin:231-330/431 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.

Function:
CCRN4L is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.

Similarity:
Belongs to the CCR4/nocturin family.

SWISS:
Q9UK39

Gene ID:
25819

Database links:

Entrez Gene: 540641 Cow

Entrez Gene: 25819 Human

Entrez Gene: 171555 Rat

Omim: 608468 Human

SwissProt: Q9UK39 Human

Unigene: 480763 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.