|别 名||CCR4 carbon catabolite repression 4 like (S. cerevisiae); CCR4 protein homolog; CCRN4L; NOC; NOCT_HUMAN.|
|交叉反应||Mouse, Rat, (predicted: Human, Chicken, Pig, Horse, Sheep, )|
|产品应用||WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||48kDa|
|免 疫 原||KLH conjugated synthetic peptide derived from human Nocturnin:231-330/431|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.|
|产品介绍||Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.|
CCRN4L is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.
Belongs to the CCR4/nocturin family.
Entrez Gene: 25819 Human
Omim: 608468 Human
SwissProt: Q9UK39 Human
Unigene: 480763 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.