KLF4重组兔单克隆抗体

产品货号：

BN42148R
中文名称：

KLF4重组兔单克隆抗体
英文名称：

Rabbit anti-KLF4 Monoclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN42148R-50ul

50ul

¥2020.00

交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt
BN42148R-100ul

100ul

¥3240.00

交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt

产品描述

英文名称	KLF4
中文名称	KLF4重组兔单克隆抗体
别名	Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor); Kruppel like factor 4 (gut); Krueppel-like factor 4;EZF;GKLF;KLF 4;KLF-4;Krueppel like factor 4; KLF4_HUMAN.
研究领域	肿瘤细胞生物信号转导干细胞细胞周期蛋白转录调节因子
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	6C5
交叉反应	Human, Mouse, (predicted: Rat, )
产品应用	WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	56kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant protein within human KLF4 aa 1-500:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor. Function: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. Subunit: Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain). Subcellular Location: Nucleus. Post-translational modifications: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. SWISS: O43474 Gene ID: 9314 Database links: Entrez Gene: 9314 Human Entrez Gene: 16600 Mouse Omim: 602253 Human SwissProt: O43474 Human SwissProt: Q60793 Mouse Unigene: 376206 Human Unigene: 4325 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.