热休克蛋白-70重组兔单克隆抗体

产品货号：

BN42115R
中文名称：

热休克蛋白-70重组兔单克隆抗体
英文名称：

Rabbit anti-HSP70 Monoclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN42115R-50ul

50ul

¥2020.00

交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,ICC,Flow-Cyt
BN42115R-100ul

100ul

¥3240.00

交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,ICC,Flow-Cyt

产品描述

英文名称	HSP70
中文名称	热休克蛋白-70重组兔单克隆抗体
别名	HSP70; HSP-70; HSP 70; Heat shock 70 kDa protein 1; heat shock 70kDa protein 1A; Heat shock 70kDa protein 1B; Heat shock induced protein; heat shock protein 70; HSP70 1; HSP70 2; HSP70.1; HSP72; HSPA1; HSPA1A; HSPA1B; XXbac BCX40G17.3 001; Heat shock 70 kDa protein 1A/1B; HSP71A_HUMAN; Hspa1a; Hsp70-1; HSP72; Hspa1; Hspa1b; Heat shock 70 kDa protein 1A/1B; shock 70 kDa protein 1/2; HSP70-1/HSP70-2; HSP70.1/HSP70.2.
研究领域	肿瘤信号转导转录调节因子
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	2G2
交叉反应	Human, Mouse, Rat,
产品应用	WB=1:1000-5000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	70kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human HSP70 around the phosphorylation site of Tyr41:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]. Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Subunit: Component of the CatSper complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7. Interacts with CHCHD3. Subcellular Location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Tissue Specificity: HSPA1B is testis-specific. Similarity: Belongs to the heat shock protein 70 family. SWISS: P0DMV8 Gene ID: 3303 Database links: Entrez Gene: 281825 Cow Entrez Gene: 3303 Human Entrez Gene: 3304 Human Entrez Gene: 15511 Mouse Entrez Gene: 193740 Mouse Entrez Gene: 24472 Rat Entrez Gene: 294254 Rat Omim: 140550 Human Omim: 603012 Human SwissProt: Q27975 Cow SwissProt: P0DMV8 Human SwissProt: P0DMV9 Human SwissProt: P17879 Mouse SwissProt: Q61696 Mouse SwissProt: Q07439 Rat Unigene: 274402 Human Unigene: 719966 Human Unigene: 728810 Human Unigene: 1950 Rat Unigene: 228225 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.