细胞角蛋白19重组兔单克隆抗体

产品货号：

BN42076R
中文名称：

细胞角蛋白19重组兔单克隆抗体
英文名称：

Rabbit anti-Cytokeratin 19 Monoclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN42076R-50ul

50ul

¥2020.00

交叉反应：Human(predicted:Mouse) 推荐应用：WB,IHC-P,IHC-F,ICC,IF
BN42076R-100ul

100ul

¥3240.00

交叉反应：Human(predicted:Mouse) 推荐应用：WB,IHC-P,IHC-F,ICC,IF

产品描述

英文名称	Cytokeratin 19
中文名称	细胞角蛋白19重组兔单克隆抗体
别名	40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd
研究领域	肿瘤细胞生物干细胞
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	2F3
交叉反应	Human, (predicted: Mouse, )
产品应用	WB=1:2000-5000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:20-100 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	44kDa
细胞定位	细胞浆细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human Cytokeratin 19 protein, around C-terminal 100aa.:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008] Function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Subunit: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein. Tissue Specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. Similarity: Belongs to the intermediate filament family. SWISS: P08727 Gene ID: 3880 Database links: Entrez Gene: 3880 Human Entrez Gene: 16669 Mouse Omim: 148020 Human SwissProt: P08727 Human SwissProt: P19001 Mouse Unigene: 654568 Human Unigene: 439699 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.