细胞色素C重组兔单克隆抗体

产品货号：

BN42074R
中文名称：

细胞色素C重组兔单克隆抗体
英文名称：

Rabbit anti-Cytochrome C Monoclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN42074R-50ul

50ul

¥2020.00

交叉反应：Rat,Mouse,Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF
BN42074R-100ul

100ul

¥3240.00

交叉反应：Rat,Mouse,Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF

产品描述

英文名称	Cytochrome C
中文名称	细胞色素C重组兔单克隆抗体
别名	CytC; CYC; CYCS; Cytochrome c somatic; HCS; CYC_HUMAN; Cytochrome-c; MSA06; THC4.
研究领域	肿瘤心血管细胞生物神经生物学信号转导细胞凋亡脂蛋白新陈代谢线粒体
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	1F10
交叉反应	Human, Mouse, Rat,
产品应用	WB=1:500-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	12.8/26kDa
细胞定位	细胞浆细胞膜线粒体
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human Cytochrome C protein, full length:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis. Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Subcellular Location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane. Post-translational modifications: Binds 1 heme group per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. DISEASE: Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation. Similarity: Belongs to the cytochrome c family. SWISS: P99999 Gene ID: 54205 Database links: Entrez Gene: 54205 Human Entrez Gene: 13063 Mouse Entrez Gene: 25309 Rat Omim: 123970 Human SwissProt: P99999 Human SwissProt: P62897 Mouse SwissProt: P62898 Rat Unigene: 437060 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.