bFGF重组兔单克隆抗体

产品货号：

BN42059R
中文名称：

bFGF重组兔单克隆抗体
英文名称：

Rabbit anti-bFGF Monoclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN42059R-50ul

50ul

¥2020.00

交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB,IHC-P,IHC-F,ELISA
BN42059R-100ul

100ul

¥3240.00

交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB,IHC-P,IHC-F,ELISA

产品描述

英文名称	bFGF
中文名称	bFGF重组兔单克隆抗体
别名	Basic fibroblast growth factor; FGF basic; FGF-basic; BFGF; FGF-2; FGF B; FGF2; FGF2 basic; FGFB; Fibroblast growth factor 2 (basic); HBGF 2; HBGF-2; HBGF2; HBGH 2; HBGH2; Heparin binding growth factor 2 precursor; Prostatropin; FGF2_HUMAN.
研究领域	肿瘤心血管细胞生物免疫学生长因子和激素内皮细胞
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	5G8
交叉反应	Human, (predicted: Mouse, Rat, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	31kDa
细胞定位	细胞核分泌型蛋白
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human bFGF:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]. Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Subcellular Location: Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57. Tissue Specificity: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue. Post-translational modifications: Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion. Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing. Similarity: Belongs to the heparin-binding growth factors family. SWISS: P09038 Gene ID: 2247 Database links: Entrez Gene: 2247 Human Entrez Gene: 14173 Mouse Entrez Gene: 54250 Rat Omim: 134920 Human SwissProt: P09038 Human SwissProt: P15655 Mouse SwissProt: P13109 Rat Unigene: 284244 Human Unigene: 473689 Mouse Unigene: 31808 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.