线粒体钙吸收蛋白单克隆抗体

产品货号：

BN42015M
中文名称：

线粒体钙吸收蛋白单克隆抗体
英文名称：

Mouse anti-CBARA1/MICU1 Monoclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN42015M-50ul

50ul

¥1486.00

交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB
BN42015M-100ul

100ul

¥2360.00

交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB

产品描述

英文名称	CBARA1/MICU1
中文名称	线粒体钙吸收蛋白单克隆抗体
别名	Mitochondrial Calcium Uptake 1; Calcium-Binding Atopy-Related Autoantigen 1; Atopy-Related Autoantigen CALC; Ara CALC; CBARA1; CALC; Calcium Binding Atopy-Related Autoantigen 1; Calcium Uptake Protein 1, Mitochondrial; Allergen Hom S 4; EFHA3; MPXPS; MICU1_HUMAN;
研究领域	细胞生物信号转导新陈代谢线粒体
抗体来源	Mouse
克隆类型	Monoclonal
克隆号	1H8
交叉反应	Human, (predicted: Mouse, Rat, )
产品应用	WB=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	54kDa
细胞定位	细胞浆线粒体
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human CBARA1 Protein (1-250/476):
亚型	IgG
纯化方法	affinity purified by Protein G
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013] Function: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). Subunit: Homohexamer; in absence of calcium (PubMed:24514027). Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium (PubMed:26489515, PubMed:24514027). Heterodimer; disulfide-linked; heterodimerizes with MICU2 (PubMed:24560927). The heterodimer formed with MICU2 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level (PubMed:26387864). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (PubMed:24231807). Interacts (via polybasic region) with EMRE/SMDT1; the interaction is direct (PubMed:27099988). Interacts (via polybasic region) with MCU (via coiled coil domains); the interaction is direct and precedes formation of the heterodimer with MICU2 (PubMed:21685886, PubMed:23101630, PubMed:23178883, PubMed:24332854, PubMed:26387864). Interacts with SLC25A23 (PubMed:24430870). Interacts with CHCHD4/MIA40; which introduces the interchain disulfide bond with MICU2 (PubMed:26387864). Subcellular Location: Mitochondrion inner membrane; Single-pass membrane protein; Mitochondrion intermembrane space Tissue Specificity: Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. Similarity: Belongs to the MICU1 family. MICU1 subfamily. Contains 2 EF-hand domains. SWISS: Q9BPX6 Gene ID: 10367 Database links: Entrez Gene: 507899 Cow Entrez Gene: 479241 Dog Entrez Gene: 10367 Human Entrez Gene: 216001 Mouse Entrez Gene: 365567 Rat Omim: 605084 Human SwissProt: Q0IIL1 Cow SwissProt: Q9BPX6 Human SwissProt: Q8VCX5 Mouse SwissProt: Q6P6Q9 Rat Unigene: 524367 Human Unigene: 27199 Mouse Unigene: 214252 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.