金属蛋白酶组织抑制因子-1单克隆抗体

产品货号：

BN41976M
中文名称：

金属蛋白酶组织抑制因子-1单克隆抗体
英文名称：

Mouse anti-TIMP-1 Monoclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41976M-50ul

50ul

¥1486.00

交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN41976M-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称	TIMP-1
中文名称	金属蛋白酶组织抑制因子-1单克隆抗体
别名	Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.
研究领域	肿瘤细胞生物神经生物学细胞凋亡生长因子和激素激酶和磷酸酶合成与降解
抗体来源	Mouse
克隆类型	Monoclonal
克隆号	4C2
交叉反应	Human, Mouse, Rat,
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:200-800 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	21kDa
细胞定位	分泌型蛋白
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human TIMP-1:
亚型	IgG
纯化方法	affinity purified by Protein G
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq]. Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Subcellular Location: Secreted. Post-translational modifications: The activity of TIMP1 is dependent on the presence of disulfide bonds. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. SWISS: P01033 Gene ID: 7076 Database links: Entrez Gene: 7076 Human Entrez Gene: 21857 Mouse Omim: 305370 Human SwissProt: P01033 Human SwissProt: P12032 Mouse Unigene: 522632 Human Unigene: 8245 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.