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首页>>免疫学>>一抗>>C-反应蛋白单克隆抗体
C-反应蛋白单克隆抗体
  • 产品货号：
    BN41971M
  • 中文名称：
    C-反应蛋白单克隆抗体
  • 英文名称：
    Mouse anti-CRP(C11F2) Monoclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41971M-50ul

    50ul

    ¥1486.00

    交叉反应：Human 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41971M-100ul

    100ul

    ¥2360.00

    交叉反应：Human 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称CRP(C11F2)
中文名称C-反应蛋白单克隆抗体
别    名C-reactive protein; C Reactive Protein; C reactive protein pentraxin related; CRP; MGC88244; PTX 1; PTX1; C-reactive protein(1-205); CRP_HUMAN; Pentraxin 1.  
研究领域心血管  染色质和核信号  信号转导  细胞凋亡  
抗体来源Mouse
克隆类型Monoclonal
克 隆 号C11F2
交叉反应Human, 
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原Recombinded CRP protein: 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.

Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Subunit:
Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Subcellular Location:
Secreted.

Tissue Specificity:
Found in plasma.

Similarity:
Belongs to the pentaxin family.
Contains 1 pentaxin domain.

SWISS:
P02741

Gene ID:
1401

Database links:

Entrez Gene: 1401 Human

Omim: 123260 Human

SwissProt: P02741 Human

Unigene: 76452 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

C-反应蛋白-CRP（C-reactive protin）是与C性肺炎球菌的多糖起反应的一种蛋白，在某些细菌的感染过程中出现在血浆中。