先心病相关蛋白TBX1抗体

产品货号：

BN41964R
中文名称：

先心病相关蛋白TBX1抗体
英文名称：

Rabbit anti-TBX1 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41964R-50ul

50ul

¥1486.00

交叉反应：Rat,Mouse,Human(predicted:Horse,Cow,Pig,Dog,Chicken) 推荐应用：WB,Flow-Cyt,ELISA
BN41964R-100ul

100ul

¥2360.00

交叉反应：Rat,Mouse,Human(predicted:Horse,Cow,Pig,Dog,Chicken) 推荐应用：WB,Flow-Cyt,ELISA
BN41964R-200ul

200ul

¥3490.00

交叉反应：Rat,Mouse,Human(predicted:Horse,Cow,Pig,Dog,Chicken) 推荐应用：WB,Flow-Cyt,ELISA

产品描述

英文名称	TBX1
中文名称	先心病相关蛋白TBX1抗体
别名	CAFS; CTHM; DGCR; DGS; DORV; T box 1; T box 1 transcription factor; T box 1 transcription factor C; T box; T box protein 1; T box transcription factor TBX 1; T box transcription factor TBX1; T-box 1; T-box protein 1; T-box transcription factor TBX1; TBX 1; TBX 1C; tbx1; TBX1_HUMAN; TBX1C; Testis specific T box protein; Testis-specific T-box protein; TGA; VCFS.
研究领域	心血管细胞生物免疫学神经生物学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=2ug/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	43kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TBX1:165-270/398
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Function: Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries. Subunit: Interacts with DSCR6. Subcellular Location: Nucleus. DISEASE: Note=Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS). DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defects, cleft palate or velar insufficiency, facial dysmorpholgy and learning difficulties. It is now accepted that these two syndromes represent two forms of clinical expression of the same entity manifesting at different stages of life. DiGeorge syndrome (DGS) [MIM:188400]: A congenital syndrome characterized by a wide spectrum of characteristics including parathyroid hypoplasia resulting in hypocalcemia, thymic hypoplasia resulting in T-cell immunodeficiency, defects in the outflow tract of the heart, and craniofacial anomalies. Disturbance of cervical neural crest migration into the derivatives of the pharyngeal arches and pouches can account for the phenotype. Note=The disease is caused by mutations affecting the gene represented in this entry. Velocardiofacial syndrome (VCFS) [MIM:192430]: A syndrome characterized by abnormal pharyngeal arch development that results in defective development of the parathyroid glands, thymus, and conotruncal region of the heart. The phenotype is highly variable, with no single clinical feature present in every patient. Affected individuals may present with structural or functional palatal abnormalities, cardiac defects, unique facial characteristics, hypernasal speech, hypotonia, and defective thymic development associated with impaired immune function. In addition, affected individuals may present with learning disabilities, overt developmental delay, and psychiatric disorders. Note=The disease is caused by mutations affecting the gene represented in this entry. Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 T-box DNA-binding domain. SWISS: O43435 Gene ID: 6899 Database links: Entrez Gene: 6899 Human Entrez Gene: 21380 Mouse Entrez Gene: 360737 Rat Omim: 602054 Human SwissProt: O43435 Human SwissProt: P70323 Mouse Unigene: 173984 Human Unigene: 295194 Mouse Unigene: 41347 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.