FK506结合蛋白38抗体

产品货号：

BN41960R
中文名称：

FK506结合蛋白38抗体
英文名称：

Rabbit anti-FKBP38 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41960R-50ul

50ul

¥1486.00

交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41960R-100ul

100ul

¥2360.00

交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41960R-200ul

200ul

¥3490.00

交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	FKBP38
中文名称	FK506结合蛋白38抗体
别名	38 kDa FK 506 binding protein homolog; 38 kDa FK506-binding protein; 38 kDa FKBP; 38kDa antibody FK506 binding protein 8; FK506 binding protein 8, 38kDa; FK506 binding protein, 38kDa; FK506-binding protein 8; FKBP 38; FKBP-38; FKBP-8; FKBP8; FKBP8_HUMAN; FKBPR38; hFKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; Rotamase; Sam11.
研究领域	细胞生物免疫学信号转导细胞凋亡转录调节因子结合蛋白
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, Rat, (predicted: Human, Chicken, Dog, Cow, Horse, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	46kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human FKBP38:255-350/412
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. Tissue specificity: Widely expressed. Highest levels seen in the brain. Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Subunit: Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. Subcellular Location: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Tissue Specificity: Widely expressed. Highest levels seen in the brain. Similarity: Contains 1 PPIase FKBP-type domain. Contains 3 TPR repeats. SWISS: Q14318 Gene ID: 23770 Database links: Entrez Gene: 23770 Human Entrez Gene: 14232 Mouse Entrez Gene: 290652 Rat Omim: 604840 Human SwissProt: Q14318 Human SwissProt: O35465 Mouse SwissProt: Q3B7U9 Rat Unigene: 173464 Human Unigene: 141864 Mouse Unigene: 99789 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.