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产品规格
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BN41953R-50ul
50ul
¥1486.00
交叉反应：Rat,Mouse(predicted:Rabbit,Cow,Human) 推荐应用：IHC-P,IHC-F,IF,ELISA
BN41953R-100ul
100ul
¥2360.00
交叉反应：Rat,Mouse(predicted:Rabbit,Cow,Human) 推荐应用：IHC-P,IHC-F,IF,ELISA
BN41953R-200ul
200ul
¥3490.00
交叉反应：Rat,Mouse(predicted:Rabbit,Cow,Human) 推荐应用：IHC-P,IHC-F,IF,ELISA
产品描述
| 英文名称 | Nidogen |
| 中文名称 | 巢蛋白1抗体 |
| 别 名 | Ent; Entactin 1; Entactin; NID 1; NID; NID-1; Nid1; Nidogen (enactin); Nidogen 1; Nidogen; Nidogen-1; NID1_HUMAN. |
| 研究领域 | 细胞生物 免疫学 神经生物学 信号转导 细胞周期蛋白 细胞粘附分子 细胞分化 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Cow, Rabbit, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 133kDa |
| 细胞定位 | 细胞膜 细胞外基质 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Entactin:1001-1100/1247 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Basement membranes are the earliest extracellular matrices produced during embryogenesis. They are synthesized and incorporated into the supramolecular architecture of several components, including laminins, Collagen IV, Nidogen and proteoglycans. Nidogen/Entactin, a sulfated glycoprotein, acts as a link between the extracellular matrix molecules Laminin 1 and Collagen Type IV, and thereby participates in the assembly of basement membranes. Nidogen is a highly conserved member of the Nidogen family, which also includes Nidogen-2. Nidogen-2 has a high level of N- and O-glycosylation, and it interacts with Collagens Type I and IV and Perlecan at a comparable level to Nidogen. Nidogen is synthesized and secreted in primary and established mesenchymal peritubular cells and myoepithelial cells, and it affects adhesion of peritubular cells in an autocrine manner. Nidogen is expressed during embryonic and fetal development exclusively in fully developed basement membranes of the ectoderm and is not expressed in the developing endodermal basement membrane or in membranes disrupted during mesoderm formation. Nidogen also cooperates with Laminin 1 to regulate b-casein expression. Function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Subunit: Interacts with FBLN1 and LGALS3BP. Interacts with PLXDC1. Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane. Post-translational modifications: N- and O-glycosylated. Similarity: Contains 6 EGF-like domains. Contains 1 NIDO domain. Contains 1 nidogen G2 beta-barrel domain. Contains 1 thyroglobulin type-1 domain. SWISS: P14543 Gene ID: 4811 Database links: Entrez Gene: 4811 Human Entrez Gene: 18073 Mouse Omim: 131390 Human SwissProt: P14543 Human SwissProt: P10493 Mouse Unigene: 356624 Human Unigene: 4691 Mouse Unigene: 105658 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
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