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首页>>免疫学>>一抗>>基质金属蛋白酶-1抗体
基质金属蛋白酶-1抗体
  • 产品货号：
    BN41906R
  • 中文名称：
    基质金属蛋白酶-1抗体
  • 英文名称：
    Rabbit anti-MMP-1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41906R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse,Rat,Rabbit(predicted:Dog,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41906R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat,Rabbit(predicted:Dog,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41906R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat,Rabbit(predicted:Dog,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称MMP-1
中文名称基质金属蛋白酶-1抗体
别    名MMP-1; MMP1; CLGN; CLG; collagenase, fibroblast; Fibroblast collagenase; Interstitial collagenase; Matrix metallopeptidase 1 (interstitial collagenase); Matrix metalloprotease 1; Matrix metalloproteinase-1; Matrix Metalloproteinase 1; MMP1_HUMAN; OTTHUMP00000045866;MMP 1.  



研究领域肿瘤  心血管  细胞生物  信号转导  细胞骨架  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Rabbit,  (predicted: Dog, Cow, Horse, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27/41/54kDa
细胞定位细胞外基质 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MMP-1:251-350/469 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.

Function:
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

Subunit:
Interacts with HIV-1 Tat.

Subcellular Location:
Secreted, extracellular space, extracellular matrix (Probable).

Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.

SWISS:
P03956

Gene ID:
4312

Database links:

Entrez Gene: 4312 Human

Entrez Gene: 17386 Mouse

Entrez Gene: 397320 Pig

Entrez Gene: 100009110 Rabbit

Omim: 120353 Human

SwissProt: P28053 Cow

SwissProt: P03956 Human

SwissProt: P33435 Mouse

SwissProt: P21692 Pig

SwissProt: P13943 Rabbit

Unigene: 83169 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

基质金属蛋白酶(matrix metalloproteinases, MMPs)是一族依赖锌离子而降解各种细胞外基质的蛋白酶，亦称IV型胶原酶或称明胶酶A，其主要功能为降解IV型胶原，因而它在肿瘤细胞突破基底膜屏障和浸润转移中起重要作用。 目前主要用于各种恶性肿瘤(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与肿瘤转移浸润的研究。