极低密度脂蛋白受体抗体

产品货号：

BN41897R
中文名称：

极低密度脂蛋白受体抗体
英文名称：

Rabbit anti-VLDL Receptor Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41897R-50ul

50ul

¥1486.00

交叉反应：Human 推荐应用：WB,ICC
BN41897R-100ul

100ul

¥2360.00

交叉反应：Human 推荐应用：WB,ICC
BN41897R-200ul

200ul

¥3490.00

交叉反应：Human 推荐应用：WB,ICC

产品描述

英文名称	VLDL Receptor
中文名称	极低密度脂蛋白受体抗体
别名	Very low density lipoprotein receptor; VLDL R; VLDLR; VLDL-R; VLDLRCH.
研究领域	肿瘤心血管免疫学神经生物学信号转导
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,
产品应用	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	93kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human VLDL Receptor:551-650/873 <Extracellular>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	VLDL (very low density lipoprotein) cholesterol is one of the three major types of cholesterol found in blood. VLDL receptor plays an essential role in triglyceride metabolism. It binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Function: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). Subunit: Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17. Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains. Subcellular Location: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Tissue Specificity: Abundant in heart and skeletal muscle; also ovary and kidney; not in liver. Post-translational modifications: Ubiquitinated at Lys-839 by MYLIP leading to degradation. DISEASE: Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1) [MIM:224050]; also known as dysequilibrium syndrome (DES) or non-progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. Similarity: Contains 3 EGF-like domains. Contains 8 LDL-receptor class A domains. Contains 6 LDL-receptor class B repeats. SWISS: P98155 Gene ID: 7436 Database links: Entrez Gene: 7436 Human Entrez Gene: 22359 Mouse Entrez Gene: 25696 Rat Omim: 192977 Human SwissProt: P98155 Human SwissProt: P98156 Mouse SwissProt: P98166 Rat Unigene: 370422 Human Unigene: 4141 Mouse Unigene: 9975 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.