谷氨酰胺合成酶/谷氨酸氨连接酶抗体

产品货号：

BN41893R
中文名称：

谷氨酰胺合成酶/谷氨酸氨连接酶抗体
英文名称：

Rabbit anti-Glutamine synthetase Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41893R-50ul

50ul

¥1486.00

交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41893R-100ul

100ul

¥2360.00

交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41893R-200ul

200ul

¥3490.00

交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	Glutamine synthetase
中文名称	谷氨酰胺合成酶/谷氨酸氨连接酶抗体
别名	cell proliferation-inducing protein 59; GLNA; GLNA_HUMAN; GLNS; GLUL; Glutamate ammonia ligase; Glutamate decarboxylase; Glutamate--ammonia ligase; glutamine synthase; Glutamine synthetase; GS; PIG 43; PIG 59; PIG43; PIG59; Proliferation inducing protein 43.
研究领域	免疫学神经生物学信号转导线粒体 Alzheimer's
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	42kDa
细胞定位	细胞浆线粒体
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Glutamine synthetase:285-373/373
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 42 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture. Function: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts. Subcellular Location: Cytoplasm. Mitochondrion. DISEASE: Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Similarity: Belongs to the glutamine synthetase family. SWISS: P15104 Gene ID: 2752 Database links: Entrez Gene: 2752 Human Entrez Gene: 281199 Cow Entrez Gene: 403443 Dog Entrez Gene: 14645 Mouse Entrez Gene: 24957 Rat Omim: 138290 Human SwissProt: P15103 Cow SwissProt: Q8HZM5 Dog SwissProt: P15104 Human SwissProt: P15105 Mouse SwissProt: P09606 Rat Unigene: 518525 Human Unigene: 210745 Mouse Unigene: 2204 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.