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BN41851R-50ul
50ul
¥1486.00
交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41851R-100ul
100ul
¥2360.00
交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41851R-200ul
200ul
¥3490.00
交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
产品描述
| 英文名称 | Klotho |
| 中文名称 | Klotho多肽蛋白抗体 |
| 别 名 | KL antibody KLOT_HUMAN; Klotho peptide. |
| 研究领域 | 肿瘤 细胞生物 免疫学 发育生物学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 113kDa |
| 细胞定位 | 细胞膜 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Klotho:401-500/1012 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. Function: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity). Subunit: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide. Isoform 2: Secreted. Klotho peptide: Secreted. Tissue Specificity: Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.hepatocellular carcinomas, and in chronic renal failure kidney. Post-translational modifications: N-glycosylated. DISEASE: Present in cortical renal tubules (at protein level). Soluble peptide is Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. Similarity: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. SWISS: Q9UEF7 Gene ID: 9365 Database links: Entrez Gene: 9365 Human Entrez Gene: 16591 Mouse Omim: 604824 Human SwissProt: Q9UEF7 Human SwissProt: O35082 Mouse Unigene: 524953 Human Unigene: 6500 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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