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产品规格
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BN41837R-50ul
50ul
¥1486.00
交叉反应：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41837R-100ul
100ul
¥2360.00
交叉反应：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41837R-200ul
200ul
¥3490.00
交叉反应：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
产品描述
| 英文名称 | Fbx32 |
| 中文名称 | 泛素蛋白连接酶抗体 |
| 别 名 | Fbx32; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein. |
| 研究领域 | 细胞生物 干细胞 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAFbx:31-130/355 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD. Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32. Subcellular Location: Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus. Tissue Specificity: Specifically expressed in cardiac and skeletal muscle. Similarity: Contains 1 F-box domain. SWISS: Q969P5 Gene ID: 114907 Database links: Entrez Gene: 114907 Human Entrez Gene: 67731 Mouse Omim: 606604 Human SwissProt: Q969P5 Human SwissProt: Q9CPU7 Mouse Unigene: 403933 Human Unigene: 292042 Mouse Unigene: 72619 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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