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产品规格
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BN41744R-50ul
50ul
¥1486.00
交叉反应：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,Flow-Cyt,ELISA
BN41744R-100ul
100ul
¥2360.00
交叉反应：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,Flow-Cyt,ELISA
BN41744R-200ul
200ul
¥3490.00
交叉反应：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,Flow-Cyt,ELISA
产品描述
| 英文名称 | CX3CR1 |
| 中文名称 | 趋化因子受体1抗体 |
| 别 名 | Beta chemokine receptor-like 1; C X3 C CKR 1; CCRL1; Chemokine C X3 C motif receptor 1; CMK BRL 1; CMKBLR1; CMK-BRL-1; CMKDR1; CX3C chemokine receptor 1; CX3C CKR1; Fractalkine Receptor; GPR13; GPRV28; V28; Chemokine receptor 1(chemokine (C-X3-C motif) receptor 1; C-X3-C CKR-1; CX3C1_HUMAN; CX3CR1; G-protein coupled receptor 13. |
| 研究领域 | 肿瘤 免疫学 神经生物学 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, (predicted: Dog, Cow, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CX3CR1:151-250/355 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] Function: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Subunit: Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in lymphoid and neural tissues. DISEASE: Age-related macular degeneration 12 (ARMD12) [MIM:613784]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P49238 Gene ID: 1524 Database links: Entrez Gene: 1524 Human Entrez Gene: 13051 Mouse Omim: 601470 Human SwissProt: P49238 Human SwissProt: Q9Z0D9 Mouse Unigene: 78913 Human Unigene: 44065 Mouse Unigene: 10482 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
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