转录因子家族ETS1抗体

产品货号：

BN41677R
中文名称：

转录因子家族ETS1抗体
英文名称：

Rabbit anti-ETS1 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41677R-50ul

50ul

¥1486.00

交叉反应：Human,Mouse,Rat,GuineaPig(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41677R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat,GuineaPig(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41677R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse,Rat,GuineaPig(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称	ETS1
中文名称	转录因子家族ETS1抗体
别名	Avian erythroblastosis virus E26 (v ets) oncogene homolog 1; C ets 1 protein; ETS 1; Ets protein; ETS-1; ETS1 protein; ETS1_HUMAN; EWSR 2; EWSR2; FLJ10768; p54; Protein C-ets-1; v ets avian erythroblastosis virus E2 oncogene homolog; v ets avian erythroblastosis virus E26 oncogene homolog 1; v ets erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1.
研究领域	肿瘤免疫学转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G)
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	49kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Ets1:321-441/441
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. Function: Transcription factor. Subunit: Interacts with MAF and MAFB. Interacts with PAX5, the interaction alters DNA-binding properties. Binds to DAXX. Interacts with UBE2I. Subcellular Location: Nucleus. Post-translational modifications: Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity. Ubiquitinated; which induces proteasomal degradation. Similarity: Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. SWISS: P14921 Gene ID: 2113 Database links: Entrez Gene: 540313 Cow Entrez Gene: 2113 Human Entrez Gene: 23871 Mouse Entrez Gene: 24356 Rat Omim: 164720 Human SwissProt: P13474 Chicken SwissProt: P15062 Chicken SwissProt: P14921 Human SwissProt: P27577 Mouse SwissProt: P41156 Rat Unigene: 369438 Human Unigene: 292415 Mouse Unigene: 88756 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Ets家族成员在胚胎发生早期的血细胞生成和血管发生及胚胎发育后期的组织发生中发挥重要的调控作用. 成年后Ets在许多组织，如造血组织、血管、脑和中枢神经系统、乳腺、子宫内膜、卵巢、睾丸、肾和肺中均有表达. 由于Ets转录因子不同成员在胚胎发育过程中的特异性的表达与其功能关系密切。 Ets家族的重要成员Ets-1的表达与胰腺癌、甲状腺癌、乳腺癌、胃癌、子宫内膜癌、口腔鳞癌、肝细胞性肝癌(HCC)的发生、转移有很重要的关系。