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产品规格
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BN41675R-50ul
50ul
¥1486.00
交叉反应：Human(predicted:Rat,Mouse) 推荐应用：WB,IHC-F,IF,Flow-Cyt,ELISA
BN41675R-100ul
100ul
¥2360.00
交叉反应：Human(predicted:Rat,Mouse) 推荐应用：WB,IHC-F,IF,Flow-Cyt,ELISA
BN41675R-200ul
200ul
¥3490.00
交叉反应：Human(predicted:Rat,Mouse) 推荐应用：WB,IHC-F,IF,Flow-Cyt,ELISA
产品描述
| 英文名称 | AQP3 |
| 中文名称 | 水通道蛋白-3抗体 |
| 别 名 | AQP 3; AQP3; Aquaporin 3 (GIL blood group); Aquaporin 3 (Gill blood group); Aquaporin3; Aquaporin-3; GIL; Gill blood group; AQP3_MOUSE. |
| 研究领域 | 肿瘤 信号转导 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse AQP3:201-292/292 <Cytoplasmic> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011] Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Renal medulla and colon. Predominantly in the inner medulla. Expressed in basal layer of epidermal keratinocytes. Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. SWISS: Q8R2N1 Gene ID: 11828 Database links: Entrez Gene: 360 Human Entrez Gene: 11828 Mouse Omim: 600170 Human SwissProt: Q92482 Human SwissProt: Q8R2N1 Mouse Unigene: 234642 Human Unigene: 34043 Mouse Unigene: 11109 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 通道蛋白（Channel Protein） AQP 3主要分布于肾脏集合管上皮细胞基侧质膜,除了对水有通透性外、还可转运尿素和甘油等小分子物质,而尿素在尿液浓缩机制中有着重要的作用. 有学者认为：AQP-3的阳性率与某些肿瘤分化程度有关（胃癌、结肠癌、乳腺癌、前列腺癌、子宫癌、卵巢癌、甲状腺癌等） |
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