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首页>>免疫学>>一抗>>核因子2相关因子2抗体
核因子2相关因子2抗体
  • 产品货号：
    BN41647R
  • 中文名称：
    核因子2相关因子2抗体
  • 英文名称：
    Rabbit anti-Nrf2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41647R-50ul

    50ul

    ¥1486.00

    交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41647R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41647R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称Nrf2
中文名称核因子2相关因子2抗体
别    名Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor erythroid derived 2 like 2; NF2L2_HUMAN.  


研究领域肿瘤  免疫学  染色质和核信号  合成与降解  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, Rabbit, )
产品应用WB=1:100-1000 ELISA=1:1000-5000 IHC-P=1:100-1000 IHC-F=1:100-1000 ICC=1:100 IF=1:100-1000 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Nrf2:401-500/605 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Function:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Subunit:
Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.

Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.

Tissue Specificity:
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Post-translational modifications:
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.

Similarity:
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.

SWISS:
Q16236

Gene ID:
4780

Database links:

Entrez Gene: 4780 Human

Omim: 600492 Human

SwissProt: Q16236 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录调节因子（Transcriptin Regulators） 核细胞系因子2相关因子Nrf2，是一种对氧化还原反应敏感的转录因子，可以通过正向促进基因的表达，来转录翻译产生一些抗氧化物，行使着异化解毒的酶类和药物的高效外排泵作用。
有学者认为：核因子2相关因子2蛋白在保护细胞免受环境毒性物质影响方面发挥着极其重要的作用，它指导某些基因促进细胞的防御工事，同时也刺激某些重要解毒酶对毒性物质，如黄曲霉素的解毒和排毒作用。