肌动蛋白α/α-SMA/α Actin抗体 - 北京拜尔迪生物技术有限公司

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肌动蛋白α/α-SMA/α Actin抗体

产品货号：

BN41621R
中文名称：

肌动蛋白α/α-SMA/α Actin抗体
英文名称：

Rabbit anti-alpha smooth muscle Actin Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41621R-50ul

50ul

¥1486.00

交叉反应：Rat,Mouse,Human(predicted:Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41621R-100ul

100ul

¥2360.00

交叉反应：Rat,Mouse,Human(predicted:Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41621R-200ul

200ul

¥3490.00

交叉反应：Rat,Mouse,Human(predicted:Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称	alpha smooth muscle Actin
中文名称	肌动蛋白α/α-SMA/α Actin抗体
别名	alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha cardiac actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5

研究领域	肿瘤细胞生物免疫学细胞骨架
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Rabbit, )
产品应用	WB=1:5000-20000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	42kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Actin alpha:165-260/377
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	All eukaryotic cells express Actin, which often constitutes as much as 50% of total cellular protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one Actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of Actin are present in mammalian tissues and fall into three classes. alpha-Actin expression is limited to various types of muscle, whereas beta- and gamma-Actin are the principle constituents of filaments in other tissues. Members of the small GTPase family regulate the organization of the Actin cytoskeleton. Rho controls the assembly of Actin stress fibers and focal adhesion. Rac regulates Actin filament accumulation at the plasma membrane. Cdc42 stimulates formation of filopodia. Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Subunit: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Subcellular Location: Cytoplasm, cytoskeleton. Post-translational modifications: Oxidation of Met-46 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced (By similarity). DISEASE: Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Similarity: Belongs to the actin family. SWISS: P62736 Gene ID: 59 Database links: Entrez Gene: 101021287 Baboon Entrez Gene: 515610 Cow Entrez Gene: 59 Human Entrez Gene: 11475 Mouse Entrez Gene: 733615 Pig Entrez Gene: 100009271 Rabbit Entrez Gene: 81633 Rat Omim: 102620 Human SwissProt: P62739 Cow SwissProt: P62736 Human SwissProt: P62737 Mouse SwissProt: P62740 Rabbit SwissProt: P62738 Rat Unigene: 500483 Human Unigene: 213025 Mouse Unigene: 195319 Rat Unigene: 3114 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Actin α/α-Actin 是一种具有收缩能力的微丝蛋白，a-SMA广泛分布于几乎所有的肌型细胞中。Actin-α蛋白主要用于检测骨骼肌、平滑肌、血管平滑肌、心肌和肌原性肿瘤包括：平滑肌瘤、平滑肌肉瘤、横纹肌肉瘤以及肌上细胞和肌上皮瘤。Actin（肌动蛋白）是在所有真核细胞中都表达的高度保守的蛋白质。它们沿微管组成了细胞骨架的主要成分。肌动蛋白至少表达为6种异构形式。它在心脏、骨骼横纹肌组织和某些平滑肌组织中表达，调节其收缩功能。有报导说肌动蛋白在乳房瘤中是高度磷酸化的。肌动蛋白的功能失调也会导致某种类型的心脏病。平滑肌α肌动蛋白使人更感兴趣，因为编码它的基因是相对局限于在血管平滑肌细胞中表达的少数几个基因之一。肌动蛋白是标记平滑肌和肌上皮细胞肿瘤的有效工具。