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产品规格
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BN41615R-50ul
50ul
¥1486.00
交叉反应：Rat(predicted:Human,Mouse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41615R-100ul
100ul
¥2360.00
交叉反应：Rat(predicted:Human,Mouse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41615R-200ul
200ul
¥3490.00
交叉反应：Rat(predicted:Human,Mouse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
产品描述
| 英文名称 | Dopamine D2 Receptor |
| 中文名称 | 多巴胺受体D2抗体 |
| 别 名 | D2DR; D2 dopamine receptor; D2R; Dopamine receptor D2; Dopamine Receptor D2L; DRD 2; DRD2; DRD2_HUMAN. |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DRD2:201-300/443 <Cytoplasmic> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | 7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins. Function: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Subcellular Location: Cell membrane. DISEASE: Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P14416 Gene ID: 1813 Database links: Entrez Gene: 1813 Human Entrez Gene: 13489 Mouse Omim: 126450 Human SwissProt: P14416 Human SwissProt: P61168 Mouse Unigene: 73893 Human Unigene: 41970 Mouse Unigene: 87299 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DAD2主要用于多态性与精神分裂症方面的研究. |
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