血小板源性生长因子A抗体

产品货号：

BN41613R
中文名称：

血小板源性生长因子A抗体
英文名称：

Rabbit anti-PDGF-A Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41613R-50ul

50ul

¥1486.00

交叉反应：Human,Mouse(predicted:Rat,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41613R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41613R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

产品描述

英文名称	PDGF-A
中文名称	血小板源性生长因子A抗体
别名	Platelet–dirived growth factor–1; PDGFA; PDGF AA; PDGF-AA; PDGF A chain; PDGF subunit A; PDGF-1; PDGF1; PDGFA; PDGFA_HUMAN; Platelet derived growth factor A chain precursor; Platelet derived growth factor alpha polypeptide; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A.
研究领域	肿瘤免疫学神经生物学生长因子和激素
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	14kDa
细胞定位	分泌型蛋白
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human PDGF-A:102-213/213
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound. Antiparallel disulfide-linked dimer of nonidentical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. The long form contains a basic insert which acts as a cell retention signal. A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. It belongs to the PDGF/VEGF growth factor family. Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4. Subcellular Location: Secreted. Note=Released by platelets upon wounding. Tissue Specificity: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Similarity: Belongs to the PDGF/VEGF growth factor family. SWISS: P01127 Gene ID: 5154 Database links: Entrez Gene: 5154 Human Entrez Gene: 5155 Human Entrez Gene: 18590 Mouse Entrez Gene: 18591 Mouse Entrez Gene: 24628 Rat Entrez Gene: 25266 Rat Omim: 173430 Human Omim: 190040 Human SwissProt: P01127 Human SwissProt: P04085 Human SwissProt: P20033 Mouse SwissProt: P31240 Mouse SwissProt: P28576 Rat SwissProt: Q05028 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PDGF-A（platelet-dirived growth factor-A）是一种碱性蛋白，pdgf促进细胞分裂、增值同时，可诱导c-fos、c-myc等蛋白表达增强。主要作用：参与组织和血管修复、促进平滑肌细胞、成纤维细胞迅速增值。分子量为28-35kDa，分为两个亚基（A、B链）通过二硫键结合而成的两条多肽链的异二聚体。最新研究发现了PDGF家族两种新的基因PDGF-C、PDGF-D。