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首页>>免疫学>>一抗>>细胞角蛋白4抗体
细胞角蛋白4抗体
  • 产品货号：
    BN41612R
  • 中文名称：
    细胞角蛋白4抗体
  • 英文名称：
    Rabbit anti-Cytokeratin 4 Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

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  • BN41612R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41612R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41612R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称Cytokeratin 4
中文名称细胞角蛋白4抗体
别    名CK 4; CK4; CYK 4; CK-4; CYK4; Cytokeratin4; Cytokeratin-4; FLJ31692; K4; Keratin 4; Keratin-4; Keratin type II cytoskeletal 4; Keratin4; KRT 4; KRT4; K2C4_HUMAN; Keratin, type II cytoskeletal 4; K4; Type-II keratin Kb4.  
研究领域肿瘤  信号转导  上皮细胞  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CK4:256-360/594 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Subunit:
Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13.

Tissue Specificity:
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.

DISEASE:
Defects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P19013

Gene ID:
3851

Database links:

Entrez Gene: 3851 Human

Omim: 123940 Human

SwissProt: P19013 Human

Unigene: 654610 Human

Unigene: 706527 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

结构蛋白（Structural Proteins）
细胞角蛋白是一类与结构相关的蛋白家族，他们在上皮细胞中形成了细胞骨架中间丝。角蛋白在上皮细胞中往往成对存在，具有组织和细胞特异性。存在于口腔黏膜、鼻腔、食道和肛门生殖器上皮中的特异角蛋白为CK4和CK13。CK4是II型角蛋白，普遍存在于非角质化的鳞状上皮细胞中，CK4表达于基底细胞，也表达于鳞状细胞癌。