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BN41601R-50ul
50ul
¥1486.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IF
BN41601R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IF
BN41601R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IF
产品描述
| 英文名称 | Leptin receptor |
| 中文名称 | 瘦素受体抗体 |
| 别 名 | obl; CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEPR; LEPROT; Leptin receptor fatty; Leptin receptor gene related protein; Leptin receptor precursor; OB R; OB-R; OB R gene related protein; OB receptor; OB-RGRP; Obr; Ob-R a/b/c/d/e; LEPR_HUMAN; LEPRD; Leptin receptor. |
| 研究领域 | 细胞生物 神经生物学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 产品应用 | WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1µg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 130kDa |
| 细胞定位 | 细胞膜 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Leptin receptor:501-600/1165 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] Function: Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway. Subunit: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits LRb signaling. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable). Tissue Specificity: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus. Post-translational modifications: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like (immunoglobulin-like) domain. SWISS: P48357 Gene ID: 3953 Database links: Entrez Gene: 3953 Human Entrez Gene: 16847 Mouse Omim: 601007 Human SwissProt: P48357 Human SwissProt: P48356 Mouse Unigene: 23581 Human Unigene: 723178 Human Unigene: 259282 Mouse Unigene: 9891 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Leptin是一种分子量为16kDa的脂肪组织源激素，由脂肪细胞分泌的，具有强亲水性，以单体形式存在于血浆中。 Leptin 具有广泛的生物学效应，作用于下丘脑，调节食欲、能量代谢及体重。Leptin 还可能作为脂肪-胰岛内分泌轴一部分，参与胰岛素分泌的调节。Leptin receptor (OB-R)是与gp130最密切相关的信号转导的共同成分,属1类细胞因子超家族，下丘脑有丰富的Leptin receptor，在其它部位也有分布，但水平较低，如：胰岛素B细胞、脉络丛、肝、肺、心、肾、睾丸、淋巴细胞和脂肪细胞中。 人类存在四个异性体，均为单跨膜受体。其中OB-Rb在胞内结构域最长，是唯一能进行信号传导并调节热量摄入和能量消耗的异性体,分子量为132kDa。 |
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