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首页>>免疫学>>一抗>>干细胞生长因子抗体
干细胞生长因子抗体
  • 产品货号：
    BN41550R
  • 中文名称：
    干细胞生长因子抗体
  • 英文名称：
    Rabbit anti-SCF Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41550R-50ul

    50ul

    ¥1486.00

    交叉反应：Rat,Mouse,Human(predicted:Goat) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41550R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat,Mouse,Human(predicted:Goat) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41550R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat,Mouse,Human(predicted:Goat) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称SCF
中文名称干细胞生长因子抗体
别    名Stem Cell Factor; C kit ligand; Ckit ligand; DKFZp686F2250; KIT ligand; Kitl; KITLG; KL 1; KL1; Mast cell growth factor; MGF; SF; SHEP7; Steel factor; Stem cell factor precursor; SCF_HUMAN.  


研究领域细胞生物  干细胞  生长因子和激素  细胞膜蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, 
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
细胞定位细胞浆 细胞膜 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SCF: 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Stem Cell Factor (SCF), also known as c-Kit ligand (KL), steel factor (SLF) and mast cell growth factor (MGF), is a 30 kDa glycoprotein with broad activities on various tissues, including hematopoietic cells, pigment cells, and primordial germ cells. SCF is secreted by endothelial cells, fibroblasts, and bone marrow stromal cells as a membrane-bound form which may be cleaved to release the soluble form. Both forms are active in promoting colony formation from murine bone marrow cells, but membrane-bound SCF is more effective in promoting hematopoieses in vivo, suggesting a role in cellular interactions between hematopoietic and stromal cells. The soluble form is thought to exist in solution as a noncovalently linked dimer. SCF is structurally related to M-CSF (CSF-1) and Flt-3/Flk-2 Ligand (FL) with all three sharing a similar size, existence of transmembrane and soluble forms, four conserved cysteines, and alternative splicing exon locations, but they share little sequence homology. SCF alone is a modest colony stimulating factor. However, in the presence of other cytokines such as EPO, TPO, GM-CSF, G-CSF, M-CSF, IL-3, and IL-7, SCF is a potent costimulant that works synergistically to increase the size of myeloid, erythroid or lymphoid lineage colonies without influencing the lineage differentiation of the progenitors.

Subunit:
Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Soluble KIT ligand: Secreted.

Similarity:
Belongs to the SCF family.

SWISS:
P21583

Gene ID:
4254

Database links:

Entrez Gene: 4254 Human

Omim: 184745 Human

SwissProt: P21583 Human

Unigene: 1048 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Stem Cell Factor(SCF,又称Kit ligand=KITLG)—干细胞生长因子。是c-kit的配体。有膜结合型和可溶型两种存在形式。具有多向性的促生长作用。