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首页>>免疫学>>一抗>>嗜铬粒素A抗体
嗜铬粒素A抗体
  • 产品货号：
    BN41548R
  • 中文名称：
    嗜铬粒素A抗体
  • 英文名称：
    Rabbit anti-Chromogranin A Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41548R-50ul

    50ul

    ¥1486.00

    交叉反应：Rat,Mouse,Human 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN41548R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat,Mouse,Human 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN41548R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat,Mouse,Human 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称Chromogranin A
中文名称嗜铬粒素A抗体
别    名beta Granin; CGA; CHG A; CHGA; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; SP I; SP1; SPI; Vasostatin; ER-37; CMGA_HUMAN.   



研究领域肿瘤  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, 
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
细胞定位细胞浆 细胞膜 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CGA:421-470/457 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008].

Function:
Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.

Subunit:
Interacts with SCG3.

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.

Post-translational modifications:
Sulfated on tyrosine residues and/or contains sulfated glycans.
O-glycosylated with core 1 or possibly core 8 glycans.

Similarity:
Belongs to the chromogranin/secretogranin proteinfamily.

SWISS:
P10645

Gene ID:
1113

Database links:

Entrez Gene: 1113 Human

Entrez Gene: 12652 Mouse

Omim: 118910 Human

SwissProt: P10645 Human

SwissProt: P26339 Mouse

Unigene: 150793 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

嗜铬粒素A蛋白存在与很多组织中：胃肠道内分泌细胞和类癌、甲状旁腺、垂体前叶、肾上腺髓质、神经节、副神经节、胰岛、甲状腺C细胞等组织和其来源的肿瘤都表达该成分.嗜铬素A（CgA）属于可溶性的酸性蛋白，主要存在于神经内分泌细胞的分泌颗粒中，也存在于含有分泌颗粒的内分泌细胞和神经内分泌细胞来源的肿瘤细胞中。检测循环中的免疫反应CgA对神经内分泌瘤具有诊断意义。另外，CgA的免疫组织化学检测对鉴定来源于神经内分泌的肿瘤起到辅助作用。