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首页>>免疫学>>一抗>>gamma氨基丁酸B型受体1抗体
gamma氨基丁酸B型受体1抗体
  • 产品货号：
    BN41546R
  • 中文名称：
    gamma氨基丁酸B型受体1抗体
  • 英文名称：
    Rabbit anti-GABABR1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

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  • BN41546R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Cow,Horse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41546R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Cow,Horse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41546R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Cow,Horse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称GABABR1
中文名称gamma氨基丁酸B型受体1抗体
别    名GABAb Receptor 1; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GAB B R1; GABA B R1; GABAB R1; GABAB subunit 1c; GABAB(1e); GABABR 1; GABABR1; GABB R1; GABBR 1; GABBR1 3; GABBR1; Gamma aminobutyric acid (GABA) B receptor 1; Gamma aminobutyric acid B receptor 1; Gamma aminobutyric acid type B receptor subunit 1; Gb 1; Gb1; GPRC 3A; GPRC3A; hGB1a; GABR1_HUMAN; Gamma-aminobutyric acid type B receptor subunit 1; GABA B Receptor 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1; Seven transmembrane helix receptor.  
研究领域神经生物学  G蛋白偶联受体  G蛋白信号  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量108kDa
细胞定位细胞浆 细胞膜 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human GABBR1 around the phosphorylation site of Ser923:651-750/961 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009].

Function:
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.
Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Subunit:
Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Isoform 1E: Secreted (Probable).

Tissue Specificity:
Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.

Similarity:
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Contains 2 Sushi (CCP/SCR) domains.

SWISS:
Q9UBS5

Gene ID:
2550

Database links:

Entrez Gene: 2550 Human

Entrez Gene: 54393 Mouse

Entrez Gene: 81657 Rat

Omim: 603540 Human

SwissProt: Q9UBS5 Human

SwissProt: Q9WV18 Mouse

SwissProt: Q9Z0U4 Rat

Unigene: 167017 Human

Unigene: 32191 Mouse

Unigene: 30059 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

g-氨基丁酸(GABA)是哺乳动物中枢神经系统中重要的抑制性神经递质，在体内通过作用于离子通道型的GABAA、GABAC受体及代谢型的GABAB受体而发挥生理功能。
GABAB1受体存在于神经元的突触前及突触后部位，介导慢的抑制性效应，在脑内参与许多重要的生理活动和病理变化，包括认知损害、癫痫、痉挛及药物成瘾等。GABAB受体属于G蛋白偶联受体家族的C家族，具有七次跨膜结构，N-端位于胞外，C-端位于胞内。