核受体相关因子-1抗体

产品货号：

BN41503R
中文名称：

核受体相关因子-1抗体
英文名称：

Rabbit anti-Nurr1 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41503R-50ul

50ul

¥1486.00

交叉反应：Human,Rat(predicted:Mouse,Pig,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41503R-100ul

100ul

¥2360.00

交叉反应：Human,Rat(predicted:Mouse,Pig,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41503R-200ul

200ul

¥3490.00

交叉反应：Human,Rat(predicted:Mouse,Pig,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	Nurr1
中文名称	核受体相关因子-1抗体
别名	Nur-ralated factor 1; Nuclear receptor-related factor 1; Orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; Regenerating liver nuclear receptor 1; RNR-1; SL-322; Nuclear orphan receptor HZF-3; T-cell nuclear receptor NOT;HZF 3; HZF3; Immediate-early response protein NOT; Intermediate early receptor protein; NGFI B/nur77 beta type transcription factor homolog; NOT; NR4A2; NR4A2_HUMAN; Nuclear receptor subfamily 4 group A member 2; Nur related protein 1 homolog; Nurr 1;RNR 1; RNR1; TINUR; Transcriptionally inducible nuclear receptor; Transcriptionally inducible nuclear receptor related; Transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor.
研究领域	染色质和核信号神经生物学新陈代谢表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Rat, (predicted: Mouse, Pig, Cow, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	67kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Nurr1:301-400/598
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Nuclear receptor and transcription factor; plays a role in development and maintenance of neurons synthesizing the neurotransmitter dopamine This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined. Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Subunit: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3 (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P43354 Gene ID: 4929 Database links: Entrez Gene: 4929 Human Entrez Gene: 18227 Mouse Entrez Gene: 54278 Rat Omim: 601828 Human SwissProt: P43354 Human SwissProt: Q06219 Mouse SwissProt: Q07917 Rat Unigene: 563344 Human Unigene: 3507 Mouse Unigene: 88129 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 该抗体和类固醇/甲状腺素受体密切相关的早期应急反应基因，也受各种生长因子的诱导。中脑多巴胺神经细胞和脑干细胞表达。