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首页>>免疫学>>一抗>>低密度脂蛋白受体的诱导降解蛋白抗体
低密度脂蛋白受体的诱导降解蛋白抗体
  • 产品货号：
    BN41398R
  • 中文名称：
    低密度脂蛋白受体的诱导降解蛋白抗体
  • 英文名称：
    Rabbit anti-MYLIP Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41398R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,ELISA

  • BN41398R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,ELISA

产品描述

英文名称MYLIP
中文名称低密度脂蛋白受体的诱导降解蛋白抗体
别    名BZF1; E3 ubiquitin protein ligase MYLIP; E3 ubiquitin-protein ligase MYLIP; Idol; Inducible degrader of the LDL-receptor; Idol; MIR; MYLIP; MYLIP_HUMAN; Myosin regulatory light chain interacting protein.  
研究领域心血管  细胞生物  信号转导  细胞周期蛋白  细胞骨架  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MYLIP:51-150/445 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Subunit:
Interacts with myosin regulatory light chain (MRLC) and TMEM4.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Autoubiquitinated.

Similarity:
Contains 1 FERM domain.
Contains 1 RING-type zinc finger.

SWISS:
Q8WY64

Gene ID:
29116

Database links:

Entrez Gene: 29116 Human

Entrez Gene: 218203 Mouse

Omim: 610082 Human

SwissProt: Q8WY64 Human

SwissProt: Q8BM54 Mouse

Unigene: 484738 Human

Unigene: 212855 Mouse

Unigene: 481228 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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