GATA结合蛋白1伴侣蛋白抗体

产品货号：

BN41387R
中文名称：

GATA结合蛋白1伴侣蛋白抗体
英文名称：

Rabbit anti-FOG1 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41387R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41387R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	FOG1
中文名称	GATA结合蛋白1伴侣蛋白抗体
别名	FOG-1; FOG1_HUMAN; Friend of GATA 1; Friend of GATA protein 1; Friend of GATA1; ZFPM1; Zinc finger protein; Zinc finger protein 89A; Zinc finger protein multitype 1; Zinc finger protein ZFPM1.
研究领域	心血管细胞生物神经生物学信号转导锌指蛋白表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	105 kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human FOG1:1-100/1006
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). Subunit: Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3. Subcellular Location: Nucleus. Tissue Specificity: Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen. Similarity: Belongs to the FOG (Friend of GATA) family. Contains 4 C2H2-type zinc fingers. Contains 5 C2HC-type zinc fingers. SWISS: Q8IX07 Gene ID: 161882 Database links: Entrez Gene: 161882 Human Omim: 601950 Human SwissProt: Q8IX07 Human Unigene: 632218 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.