X射线修复交叉互补蛋白4抗体

产品货号：

BN41334R
中文名称：

X射线修复交叉互补蛋白4抗体
英文名称：

Rabbit anti-XRCC4 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41334R-100ul

100ul

¥2360.00

交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,ELISA
BN41334R-200ul

200ul

¥3490.00

交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,ELISA

产品描述

英文名称	XRCC4
中文名称	X射线修复交叉互补蛋白4抗体
别名	DNA double strand break repair and V(D)J recombination protein XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4; DNA repair protein XRCC4; DNA-repair protein XRCC4; X ray repair complementing defective repair in Chinese hamster cells 4 ; X ray repair cross complementing protein 4; X-ray repair complementing defective repair in Chinese hamster cells 4 ; X-ray repair cross-complementing protein 4; XRCC 4; XRCC-4; XRCC4_HUMAN.
研究领域	细胞生物免疫学信号转导表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	38/60kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human XRCC4:151-260/336
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation. Function: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Subunit: Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC. Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA. Phosphorylation by CK2 promotes interaction with APTX. Monoubiquitinated. Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no effect on ubiquitination. Similarity: Belongs to the XRCC4 family. SWISS: Q13426 Gene ID: 7518 Database links: Entrez Gene: 7518 Human Omim: 194363 Human SwissProt: Q13426 Human Unigene: 567359 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.