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产品规格
售价
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BN41318R-100ul
100ul
¥2360.00
交叉反应：Mouse,Rat(predicted:Human,Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41318R-200ul
200ul
¥3490.00
交叉反应：Mouse,Rat(predicted:Human,Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
产品描述
| 英文名称 | LRRC59 |
| 中文名称 | LRRC59蛋白抗体 |
| 别 名 | Leucine-rich repeat-containing protein 59; LRC59_HUMAN; LRRC59; PRO1855. |
| 研究领域 | 细胞生物 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Dog, Horse, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRRC59:21-120/307 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | LRRC59 (leucine rich repeat containing 59), also known as PRO1855, is a 307 amino acid protein that contains leucine-rich repeats and may play a role in protein binding events throughout the cell. The gene encoding LRRC59 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. Subunit: Can form homodimers. Interacts with SGOL1. Interacts with FGF1. Subcellular Location: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1. Tissue Specificity: Widely expressed. Similarity: Contains 5 LRR (leucine-rich) repeats. SWISS: Q96AG4 Gene ID: 55379 Database links: Entrez Gene: 55379 Human Entrez Gene: 98238 Mouse Omim: 614854 Human SwissProt: Q96AG4 Human SwissProt: Q922Q8 Mouse Unigene: 370927 Human Unigene: 172720 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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