转录增强因子TEF4抗体

产品货号：

BN41310R
中文名称：

转录增强因子TEF4抗体
英文名称：

Rabbit anti-TEF4 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41310R-100ul

100ul

¥2360.00

交叉反应：Rat,Mouse(predicted:Rabbit,Horse,Cow,Dog,Human) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41310R-200ul

200ul

¥3490.00

交叉反应：Rat,Mouse(predicted:Rabbit,Horse,Cow,Dog,Human) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	TEF4
中文名称	转录增强因子TEF4抗体
别名	Embryonic TEA domain containing factor; Etdf; ETEF 1; ETF; TEA domain family member 2; TEAD 2; TEAD-2; TEAD2; Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b); TEAD2_HUMAN; TEF 4; TEF4; Transcriptional enhancer factor 4; Transcriptional enhancer factor TEF 4; Transcriptional enhancer factor TEF-4.
研究领域	细胞生物免疫学转录调节因子表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, )
产品应用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	49kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TEA domain family member 2:235-340/447
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	TEF-4 is strongly coexpressed with TEF-1 in mouse mitotic neuroblasts and is also detected in the gut and the nephrogenic region of the kidney. TEF-4 associates with the powerful transcriptional coactivator YAP65 to mediate mitogenic signals. In addition, TEF-4 promotes the activation of the CTP:phosphocholine cytidylyltransferase (CCT) alpha protein, which is the rate-limiting enzyme of phosphatidylcholine biosynthesis, by enhancing the transcriptional activity of Ets-1. Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Subunit: Interacts with YAP1 and WWTR1/TAZ. Subcellular Location: Nucleus. Similarity: Contains 1 TEA DNA-binding domain. SWISS: Q15562 Gene ID: 8463 Database links: Entrez Gene: 8463 Human Entrez Gene: 21677 Mouse Entrez Gene: 308582 Rat Omim: 601729 Human SwissProt: Q15562 Human SwissProt: P48301 Mouse Unigene: 515534 Human Unigene: 3019 Mouse Unigene: 130442 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.