细胞分裂周期样激酶2抗体

产品货号：

BN41285R
中文名称：

细胞分裂周期样激酶2抗体
英文名称：

Rabbit anti-CLK2 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41285R-100ul

100ul

¥2360.00

交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41285R-200ul

200ul

¥3490.00

交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	CLK2
中文名称	细胞分裂周期样激酶2抗体
别名	CDC like kinase 2; CLK 2; CLK kinase; Clk2 Scamp3; Dual specificity protein kinase CLK2; hCLK 2; hCLK2; MGC61500; Tu52; CLK2_HUMAN.
研究领域	细胞生物信号转导细胞周期蛋白激酶和磷酸酶细胞分化表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	60kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human CLK2:401-499/499
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	CDC-like kinase 2 (CLK2) belongs to a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases), which have been shown to phosphorylate serine- and arginine-rich (SR) proteins of the spliceosomal complex, and to influence alternative splicing in overexpression systems. Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the CLK2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length. Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Subunit: Interacts with RBMX. Interacts with AKT1 and UBL5. Subcellular Location: Isoform 1: Nucleus. Nucleus speckle. Isoform 2: Nucleus speckle. Tissue Specificity: Endothelial cells. Post-translational modifications: Autophosphorylates on all three types of residues. Phosphorylation on Ser-34 and Thr-127 by AKT1 is induced by ionizing radiation or insulin. Phosphorylation plays a critical role in cell proliferation following low dose radiation and prevents cell death following high dose radiation. Phosphorylation at Thr-344 by PKB/AKT2 induces its kinase activity which is required for its stability. The phosphorylation status at Ser-142 influences its subnuclear localization; inhbition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Contains 1 protein kinase domain. SWISS: P49760 Gene ID: 1196 Database links: UniProtKB/Swiss-Prot: P49760.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.