泛素结合酶E2变异体1抗体

产品货号：

BN41282R
中文名称：

泛素结合酶E2变异体1抗体
英文名称：

Rabbit anti-UBE2V1 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41282R-100ul

100ul

¥2360.00

交叉反应：Human,Rat(predicted:Mouse,Chicken,Pig,Horse,Sheep) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41282R-200ul

200ul

¥3490.00

交叉反应：Human,Rat(predicted:Mouse,Chicken,Pig,Horse,Sheep) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称	UBE2V1
中文名称	泛素结合酶E2变异体1抗体
别名	CIR1; CROC-1; CROC1; CROC1A; TRAF6-regulated IKK activator 1 beta Uev1A; UB2V1_HUMAN; UBE2V 1; UBE2V; UBE2V1; Ubiquitin conjugating enzyme E2 variant 1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; UEV1.
研究领域	细胞生物染色质和核信号信号转导细胞周期蛋白细胞分化表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Rat, (predicted: Mouse, Chicken, Pig, Horse, Sheep, )
产品应用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	16kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human UBE2V1:51-147/147
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Function: Has no ubiquitin ligase activity on its own. TheUBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonicalpoly-ubiquitin chains that are linked through Lys-63. This type ofpoly-ubiquitination activates IKK and does not seem to involveprotein degradation by the proteasome. Plays a role in theactivation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.Mediates transcriptional activation of target genes. Plays a rolein the control of progress through the cell cycle anddifferentiation. Plays a role in the error-free DNA repair pathwayand contributes to the survival of cells after DNA damage. Subunit: Heterodimer with UBE2N. Interacts (UBE2V2-UBE2Nheterodimer) with the E3 ligase STUB1 (via the U-box domain); thecomplex has a specific 'Lys-63'-linked polyubiquitination activity.Interacts with TRAF6. Subcellular Location: Nucleus. Note=Excluded from the nucleolus. Tissue Specificity: Highly expressed in thyroid, pancreas, spinalcord, lymph node, trachea, adrenal gland, bone marrow and pancreas.Detected at low levels in heart, breast, placenta, brain, liver,kidney, stomach and lung. Similarity: Belongs to the ubiquitin-conjugating enzyme family. SWISS: Q13404 Gene ID: 387522 Database links: Entrez Gene: 387522 Human Entrez Gene: 7335 Human Entrez Gene: 66589 Mouse Entrez Gene: 296390 Rat Omim: 602995 Human SwissProt: Q13404 Human SwissProt: Q9CZY3 Mouse Unigene: 420529 Human Unigene: 727525 Human Unigene: 278783 Mouse Unigene: 360108 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.