细胞分裂周期蛋白2抗体

产品货号：

BN41274R
中文名称：

细胞分裂周期蛋白2抗体
英文名称：

Rabbit anti-CDCA2 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41274R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41274R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	CDCA2
中文名称	细胞分裂周期蛋白2抗体
别名	cell division cycle associated 2; Recruits PP1 onto mitotic chromatin at anaphase protein; Repo Man; Repo-Man; CDCA2_HUMAN.
研究领域	细胞生物细胞周期蛋白细胞分化表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Dog, Pig, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	113kDa
细胞定位	细胞核细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human CDCA2:361-450/1023
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	CDCA2 is a regulator of chromosome structure during mitosis. CDCA2 forms an essential complex with protein phosphatase PP1-gamma subunit 1 (PPP1CC) and is required for the recruitment of PP1 to chromatin. Knockdown of CDCA2 by RNAi causes large-scale cell death by apoptosis, as does overexpression of a dominant-negative mutant of the protein. Function: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. Subunit: Interacts with PPP1CC. Subcellular Location: Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin. [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69YH5-1; Sequence=Displayed; Name=2; IsoId=Q69YH5-2; Sequence=VSP_025598, VSP_025599; Note=No experimental confirmation available. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Phosphorylated by CDK1. May regulate its subcellular location. SWISS: Q69YH5 Gene ID: 157313 Database links: Entrez Gene: 157313 Human SwissProt: Q69YH5 Human Unigene: 33366 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.