染色体结构维持蛋白6抗体

产品货号：

BN41268R
中文名称：

染色体结构维持蛋白6抗体
英文名称：

Rabbit anti-SMC6 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41268R-100ul

100ul

¥2360.00

交叉反应：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41268R-200ul

200ul

¥3490.00

交叉反应：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	SMC6
中文名称	染色体结构维持蛋白6抗体
别名	SMC6L1; SMC 6; SMC6; SMC6 protein; SMC6 structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes 6; Structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes protein 6.
研究领域	细胞生物细胞周期蛋白细胞分化表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	126 kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human SMC6:155-260/1091
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	SMC5/6 complex is recruited to nuclease induced double strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. The human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. Function: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Subunit: Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed. Overexpressed in testis. Post-translational modifications: Ubiquitinated. Similarity: Belongs to the SMC family. SMC6 subfamily. SWISS: Q96SB8 Gene ID: 79677 Database links: UniProtKB/Swiss-Prot: Q96SB8.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.