在线咨询
English
最近搜索：细胞培养 微生物学 分子生物 生物化学
最近搜索：细胞培养 微生物学 分子生物 生物化学
首页>>免疫学>>一抗>>细胞表面免疫球蛋白样转录因子4抗体
细胞表面免疫球蛋白样转录因子4抗体
  • 产品货号：
    BN41249R
  • 中文名称：
    细胞表面免疫球蛋白样转录因子4抗体
  • 英文名称：
    Rabbit anti-LILRB2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN41249R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human) 推荐应用：WB,ELISA

  • BN41249R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human) 推荐应用：WB,ELISA

产品描述

英文名称LILRB2
中文名称细胞表面免疫球蛋白样转录因子4抗体
别    名CD85D; CD85 antigen-like family member D; CD85d; CD85d antigen; ILT 4; ILT-4; ILT4; Immunoglobulin like transcript 4; Immunoglobulin-like transcript 4; Leukocyte immunoglobulin like receptor 2; Leukocyte immunoglobulin like receptor subfamily B member 2; Leukocyte immunoglobulin-like receptor 2; Leukocyte immunoglobulin-like receptor subfamily B member 2; Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LILRA6; LILRB2; LIR 2; LIR-2; LIR2; LIRb; LIRB2_HUMAN; MIR 10; MIR-10; MIR10; Monocyte/macrophage immunoglobulin like receptor 10; Monocyte/macrophage immunoglobulin-like receptor 10.  
研究领域细胞生物  细胞膜受体  细胞表面分子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LILRB2:1-100/598 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. These receptors all contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), have an inhibitory function and are type I membrane proteins. When they bind to MHC (or other ligands) and ITIM is tyrosine phosphorylated, protein-tyrosine phosphatases are recruited and an inhibitory signal cascade triggered. ILT-4, also designated LIR-2, MIR-10 or CD85D antigen, competes with CD8A for binding to class I MHC antigens.

Function:
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.

Post-translational modifications:
Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.

Similarity:
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
Q8N423

Gene ID:
10288

Database links:

Entrez Gene: 10288 Human

Omim: 604815 Human

SwissProt: Q8N423 Human

Unigene: 655652 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.