死亡效应结构域蛋白1抗体

产品货号：

BN41244R
中文名称：

死亡效应结构域蛋白1抗体
英文名称：

Rabbit anti-DEDD1 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41244R-100ul

100ul

¥2360.00

交叉反应：Human,Rat(predicted:Mouse,Chicken,Pig,Cow) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41244R-200ul

200ul

¥3490.00

交叉反应：Human,Rat(predicted:Mouse,Chicken,Pig,Cow) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	DEDD1
中文名称	死亡效应结构域蛋白1抗体
别名	CASP8IP1; Death effector domain containing; Death effector domain containing protein; Death effector domain containing testicular molecule; DEDD 1; DEDD1; DEDPro 1; DEDPro1; DEFT; FLDED 1; FLDED1; KE 05; KE05; OTTHUMP00000031822.
研究领域	肿瘤细胞生物细胞凋亡
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Rat, (predicted: Mouse, Chicken, Pig, Cow, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	35kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human DEDD1:151-250/318
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. Subunit: Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2. Subcellular Location: Cytoplasm. Nucleus, nucleolus. Tissue Specificity: Widely expressed with highest levels in testis. Post-translational modifications: Exists predominantly in a mono- or diubiquitinated form. Similarity: Contains 1 DED (death effector) domain. SWISS: O75618 Gene ID: 9191 Database links: Entrez Gene: 9191 Human Entrez Gene: 21945 Mouse Entrez Gene: 83631 Rat Omim: 606841 Human SwissProt: O75618 Human SwissProt: Q9Z1L3 Mouse SwissProt: Q9Z2K0 Rat Unigene: 146406 Human Unigene: 270139 Mouse Unigene: 203286 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.