丝裂原活化蛋白激酶组织蛋白1抗体

产品货号：

BN41229R
中文名称：

丝裂原活化蛋白激酶组织蛋白1抗体
英文名称：

Rabbit anti-MAPK organizer 1 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41229R-100ul

100ul

¥2360.00

交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41229R-200ul

200ul

¥3490.00

交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	MAPK organizer 1
中文名称	丝裂原活化蛋白激酶组织蛋白1抗体
别名	MAPK organizer 1; MGC4238; Mitogen activated protein kinase organizer 1; Mitogen-activated protein kinase organizer 1; MORG 1; WD repeat domain-containing protein 83; wdr83; WDR83_HUMAN.
研究领域	心血管细胞生物信号转导激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	35kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human MAPK organizer 1:201-315/315
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Function: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. Subunit: Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1. Identified in the spliceosome C complex. Subcellular Location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. Similarity: Belongs to the WD repeat MORG1 family. Contains 7 WD repeats. SWISS: Q9BRX9 Gene ID: 84292 Database links: Entrez Gene: 84292 Human Entrez Gene: 67836 Mouse Entrez Gene: 288924 Rat SwissProt: Q9BRX9 Human SwissProt: Q9DAJ4 Mouse SwissProt: Q5BLX8 Rat Unigene: 657204 Human Unigene: 334680 Mouse Unigene: 3570 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.