泛素特异性蛋白酶28抗体

产品货号：

BN41171R
中文名称：

泛素特异性蛋白酶28抗体
英文名称：

Rabbit anti-USP28 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41171R-100ul

100ul

¥2360.00

交叉反应：Mouse(predicted:Human,Rat) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41171R-200ul

200ul

¥3490.00

交叉反应：Mouse(predicted:Human,Rat) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	USP28
中文名称	泛素特异性蛋白酶28抗体
别名	Deubiquitinating enzyme 28; KIAA1515; Ubiquitin carboxyl terminal hydrolase 28; Ubiquitin carboxyl-terminal hydrolase 28; Ubiquitin specific peptidase 28; Ubiquitin specific processing protease 28; Ubiquitin specific protease 28; Ubiquitin thioesterase 28; Ubiquitin thiolesterase 28; Ubiquitin-specific-processing protease 28; UBP28_HUMAN; USP 28; USP28; USP28 protein.
研究领域	肿瘤细胞生物免疫学染色质和核信号
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, (predicted: Human, Rat, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	75/100kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human USP28:101-200/1077
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. SWISS: Q96RU2 Gene ID: 57646 Database links: Entrez Gene: 57646 Human Entrez Gene: 235323 Mouse Entrez Gene: 315639 Rat Omim: 610748 Human SwissProt: Q96RU2 Human SwissProt: Q5I043 Mouse SwissProt: D3ZJ96 Rat Unigene: 503891 Human Unigene: 21630 Mouse Unigene: 6599 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.